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KMID : 0363020030330040599
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Journal of Korean Academy of Periodontology
2003 Volume.33 No. 4 p.599 ~ p.613
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The effects of polylactic/polyglycolic copolymer (PLA/PGA) membrane on the healing of 1-wall intrabony defects in beagle dogs
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김성구
황성준/김민경/김창성/이덕연/이용근/조규성/채중규/김종관/최성호
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Abstract
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The goal of periodontal treatment is regeneration of the periodontium. Bone graft and absorbable PLA/PGA membrane have been used for this purpose. In this study, 4×4mm 1-wall intrabony defects were surgically created bilaterally in the mandible of five male beagles. The control group went through a conventional flap operation, while the experimental group I was treated with absorbable PLA/PGA membranes only, group II was treated with absorbable membrane and calcium phosphate.
The results are the following:
1. The defect height was 4.82±0.45mm in the control group, 4.93±0.79mm in the experimental I group, and 4.92±0.62mm in the experimental II group. There was no statistically significant difference among 3 groups(P<0.05).
2. The amount of junctional epithelium migration was 30.90±9.92% of the defect height in the control group, 39.16±7.51% in the experimental I group, and 38.68±12.22% in the experimental II group. There was no statistically significant difference among 3 groups(P<0.05).
3. The amount of connective tissue adhesion was 36.38±9.03% in the control group, 14.73±3.93% in experimental I group, and 27.87±9.70% experimental II group. Experimental group I was a statistically significantly different from control group(P<0.05).
4. The amount of new cementum regeneration was 32.92±10.51%, 50.04±7.61%, and 39.62±12.14% for the control, experimental I, and experimental II group respectively. Experimental group I was a statistically significantly different from control group(P<0.05).
5. The amount of new alveolar bone regeneration was 27.24±7.49%, 40.75±8.03%, and 36.47±15.11% for the control, experimental I, and experimental II group respectively. Experimental group I was a statistically significantly different from control group(P<0.05).
The results suggest that the use of PLA/PGA membrane in 1-wall intrabony defect of beagle dogs may promote periodontal regeneration. Further studies are required to determine their regeneration effects.
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KEYWORD
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PLA/PGA membrane, calcium phosphate, 1-wall defects, periodontal regeneration
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